this post was submitted on 28 Jul 2023
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Interesting read. A few years ago I developed, seemingly overnight, an intolerance for red meat. Which sucked cause I really like it. But I developed it while working in the arctic, where there are no ticks (but like trillions of other biting insects). Doctors just did the usual rotation of antibiotics and then said IBS and patted themselves on the back. It was a terrible cop-out, but when living in the arctic you don't get much choice for doctors. Over time the problem largely tapered off and I'm no longer a firehose an hour after eating meat. I feel for anyone who gets this.
I'm hoping that AI really helps within the field of medicine. Doctors cannot be expected to know every possible cause of every illness -- they're human after all. But I'm hoping that the weird stuff can be detected and at least diagnosed properly.
I'm so mad at Elizabeth Holmes. Any startup in this space will face such an uphill battle.
you should see what the eczema community put up with. Essentially it’s a community of just talking each other out of committing suicide because of how much pain they live with every day and the entire medical industry has failed them so miserably by dismissing them.
“Try the elimination diet” is the best they are given with absolutely no “why” or extension to find a better solution to allergies than either avoid the triggers (if you’re even lucky enough to find out what they are) or try a life threatening injection if your allergy gets severe.
Then you have the celiac community and what they have to put up with doctors: “eat gluten for 3 weeks without killing yourself so I can diagnose that you actually are intolerant to gluten”. The community has lovingly referred to this now as “the gluten challenge”….. which the medical community went as far as to take offence to the name. I wish empathy was taught as part of the curriculum for being a doctor.
I work in drug development, and have done a lot of work in topical drug development, specifically for skin diseases. Psoriasis gets most of the attention, but there's a lot of work being done on other skin diseases, as well
"Eczema" is kind of a catch-all term for a group of diseases, which is one of the reasons treatment is so difficult. One kind is often mistaken for (or even indistinguishable from) another. The most common, though, is atopic dermatitis (which is hilarious when you look up the etymology).
So that said.... Have you tried JAK inhibitors? Ruxolitinib is one of the best ones, formulated as a cream called Opzelura. It's at least good for flare ups.
Unfortunately, there aren't really any good drugs for preventing it. If you want company on that one, talk to the asthma community.
But.... There is work being done. I've worked on it. I've had companies spend millions on the work. I haven't seen anything very promising, but maybe you can take some comfort that there are frustrated scientists working on it, and pharma companies poised to take all of your money once something is found.