Infertility/miscarriage, menopause, loss of breasts or uterus to cancer, perhaps being unable to attract a partner or being 'friend zoned', trouble bonding with child maybe caused by ppd, loss of hair, accidently mistaken as being a man, failure at traditionally seen as women's work such as cooking or keeping a clean house
And I'm not sure effeminization is right. When I hear that, I think of a feminized male, not a defeminized female.
I liked star trek as a kid, so my dad would download me, I think usenet, messages from a boards discussing it. But he didn't want me overwhelmed, so maybe only 30 messages a day I could read after school, so I'd get random snippets of people arguing whether Kirk or Picard was better, or discussing the difference in klingons between the two series.